Humoral immunity and transcriptome differences of COVID-19 inactivated vacciane and protein subunit vaccine as third booster dose in humanArticle Published on 2022-10-212022-11-16 Journal: Frontiers in Immunology [Category] 변종, 유전자 메커니즘, [키워드] analyzed antibody approach booster booster dose caused correlation COVID-19 differentially expressed gene dose effective Effectiveness Efficacy Factor Health help Heterologous homologous humoral humoral immune response Humoral immunity immune Immune escape immune response Immunity immunization inactivated Inactivated vaccine indicated innate immune function innate immune pathways participant Perspective Prevalence protein subunit vaccine provided significantly Support System third booster vaccine transcriptional response Transcriptome transcriptome analysis transcriptomic analysis vaccination Vaccine variants of concern variants of concern. VOCs with COVID-19 [DOI] 10.3389/fimmu.2022.1027180 PMC 바로가기
Social connection and gene regulation during the COVID-19 pandemic: Divergent patterns for online and in-person interactionArticle Published on 2022-10-012022-11-15 Journal: Psychoneuroendocrinology [Category] 치료제, [키워드] absence analyzed antibody production antiviral immunity antiviral response association blood sample characterized connection conserved COVID-19 COVID-19 pandemic CTRA disease risk down-regulation Effect eudaimonia examined experience Factors female Gene Expression Health healthy Immune cell immune system Interaction Linear model loneliness measure Multiple offset Online social interaction profile proinflammatory gene quantified question reduced Regulation RNA Social genomics. social interaction transcriptional response [DOI] 10.1016/j.psyneuen.2022.105885 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
Mouse models of COVID-19 recapitulate inflammatory pathways rather than gene expressionArticle Published on 2022-09-262022-11-16 Journal: PLoS Pathogens [Category] SARS, 유전자 메커니즘, [키워드] ACE2 analysis approach bioinformatics Concordance COVID-19 debatable differentially expressed gene expressed expression Gene Expression hACE2 Human immune signature Immunity immunopathology inflammatory pathway K18-hACE2 lung damage Lungs mice mouse model orthologue overlap promoter SARS-CoV-2 single copy transcriptional profile transcriptional response Treatment Viral load virus wild-type [DOI] 10.1371/journal.ppat.1010867 PMC 바로가기
mTOR regulation of metabolism limits LPS-induced monocyte inflammatory and procoagulant responses Research Published on 2022-08-262022-10-05 Journal: Communications Biology [Category] 바이오마커, 진단, [키워드] activate analysis cardiovascular disease catalytic Coagulopathy expression gene product IL-1β IL-6 immune cell type Inflammatory Inflammatory response limit LPS mechanism metabolism monocyte Monocytes mTOR inhibitor NAD+ pathway polyfunctional responses primary human monocyte pro-inflammatory pro-inflammatory cytokine procoagulant Regulation response risk Support tested tissue TLR4 transcriptional activity transcriptional response Treatment with HIV [DOI] 10.1038/s42003-022-03804-z [Article Type] Research
Enrichment analysis on regulatory subspaces: A novel direction for the superior description of cellular responses to SARS-CoV-2규제 부분 공간에 대한 농축 분석: SARS-CoV-2에 대한 세포 반응의 우수한 설명을 위한 새로운 방향Article Published on 2022-07-012022-09-11 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 변종, 신종인플루엔자, [키워드] affected Algorithm Analysis applied Biclustering Cell cell line cellular response Characteristics classic Clustering Comparative analysis complex Computational biology Coverage COVID-19 database Discriminative regulatory patterns enrichment enrichment analysis False positive functional enrichment Functional enrichment analysis GO term GO terms H1N1 IAV identify Impact IMPROVE in vivo infected cell infected cells Interaction KEGG pathway knowledge knowledge extraction lack lung cell line lung cell lines machine machine learning machine learning algorithm machine learning approach motivation observations pathophysiological performed Predictive Regulatory RSV SARS-CoV-1 SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus scarcity significantly the SARS-CoV-2 virus transcriptional response transcriptomic data transcriptomics transcriptomics. variant virus viruses [DOI] 10.1016/j.compbiomed.2022.105443 PMC 바로가기 [Article Type] Article
Specialized interferon action in COVID-19코로나19에 특화된 인터페론 작용Article Published on 2022-03-152022-09-11 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, 유전자 메커니즘, 진단, [키워드] Activation Antiviral association C-reactive protein cell types circulating clinical marker clinical markers COVID-19 COVID-19 pathology CyTOF cytokine diagnostic disease severity Effect endothelial damage example Hospitalization hospitalized COVID-19 patients IFN IFN signaling IFNA2 IFNA6 IFNB1 IFNg IFNs Immune cell immune cell types immune cells immune marker Impact Implications interferon interferon. Kynurenine Kynurenine pathway lymphocyte lymphoid marker neutrophil pathology platelet activation poor prognosis Protective proteomics SARS-CoV-2 Seroconversion severe disease Signaling significant decrease subset the strongest therapeutic transcriptional response type I unique [DOI] 10.1073/pnas.2116730119 PMC 바로가기 [Article Type] Article
Dual RNA-Seq analysis of SARS-CoV-2 correlates specific human transcriptional response pathways directly to viral expressionSARS-CoV-2의 이중 RNA-Seq 분석은 특정 인간 전사 반응 경로를 바이러스 발현과 직접 연관시킵니다Article Published on 2022-01-252022-09-10 Journal: Scientific Reports [Category] SARS, 유전자 메커니즘, 치료제, [키워드] Analysis approach bioinformatics cascade caused chemokine coronavirus determine differential expression Differential expression analysis drug target Effect explain expression future therapeutic Health help highlight host responses in viral Infection introduced involved lipopolysaccharide mechanism new strain offer pathway Pathways Patient promise reaction Research RNA sequencing SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 transcriptomes Society specificity therapeutic intervention therapeutic interventions tissue transcriptional response transcriptomes transcriptomic Vaccine Vaccines Viral viral infection virus [DOI] 10.1038/s41598-022-05342-4 PMC 바로가기 [Article Type] Article
Regulation of gliotoxin biosynthesis and protection in Aspergillus species아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절Research Article Published on 2022-01-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence [DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article
Transcriptomic Profiles Reveal Downregulation of Low-Density Lipoprotein Particle Receptor Pathway Activity in Patients Surviving Severe COVID-19심각한 COVID-19에서 생존한 환자의 저밀도 지단백질 입자 수용체 경로 활동의 하향 조절을 나타내는 전사체 프로필Article Published on 2021-12-102022-09-11 Journal: Cells [Category] SARS, 유전자 메커니즘, [키워드] activity AnxA2 applied approach bioinformatics Biology cargo receptor activity CD36 characterized cholesterol cholesterol homeostasis COVID-19 COVID-19 infection died disease downregulation Endpoint expression Gene expression profiling generate GO ontology Infection intensive care unit ITGAV LDL LDL particle receptor activity leukocyte leukocyte differentiation lipoprotein low-density Low-density lipoprotein mononuclear cell mononuclear cells nonsurvivor nonsurvivors Particle pathway Patient patients who survived patients with COVID-19 patients with SARS-CoV-2 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPARG profile Prognosis receptor reduced RNA-seq analysis Russia SARS-COV-2 infection severe COVID-19 STAB1 state surviving patient survivor transcriptional transcriptional response Transcriptome university virus [DOI] 10.3390/cells10123495 PMC 바로가기 [Article Type] Article